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Development of a model for robust and exploratory analysis of the rodent brief-access taste aversion data

Soto, J; Sheng, Y; Standing, JF; Orlu Gul, M; Tuleu, C; (2015) Development of a model for robust and exploratory analysis of the rodent brief-access taste aversion data. European Journal of Pharmaceutics and Biopharmaceutics , 91 47 - 51. 10.1016/j.ejpb.2015.01.016. Green open access

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Abstract

The rodent brief-access taste aversion (BATA) model is an efficient in vivo screening tool for taste assessment. A new Emax (maximum effect attributable to the drug) model was developed and further investigated in comparison with three previously published models for analysing the rodent BATA data; the robustness of all the models was discussed. The rodent BATA data were obtained from a series of experiments conducted with a bitter reference compound, quinine hydrochloride dihydrate (QHD). A new Emax model that could be applied to both "lick numbers" and "lick ratios" was built and three published models that used lick ratios were employed for analysing the BATA data. IC50, the concentration that inhibits 50% of the maximum lick numbers, quantified the oral aversiveness of QHD. One thousand bootstrap datasets were generated from the original data. All models were applied to estimate the confidence intervals of the IC50s without symmetric assumption. The IC50 value obtained from the new Emax model was 0.0496mM (95% CI 0.0297-0.0857) using the lick numbers for analysis, while an IC50 of 0.0502mM (95% CI 0.0267-0.0859) was acquired with the lick ratios. Except one published model, the IC50 values have a similar range for the 95% CI. The new Emax model enabled the analysis of both "lick numbers" and "lick ratios" whereas other models could only handle data presented as "lick ratios". IC50s obtained with these two types of datasets showed similarity among all models thereby justified the robustness of the new Emax model.

Type: Article
Title: Development of a model for robust and exploratory analysis of the rodent brief-access taste aversion data
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ejpb.2015.01.016
Publisher version: http://dx.doi.org/10.1016/j.ejpb.2015.01.016
Language: English
Additional information: © Elsevier 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. Access may be initially be restricted by the publisher.
Keywords: Bitterness, Brief-access taste aversion, E(max) model, Lickometer, NONMEM, Quinine
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1461181
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