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Silicone rubber encapsulation for an endoscopically implantable gastrostimulator

Lonys, L; Vanhoestenberghe, A; Julémont, N; Godet, S; Delplancke, MP; Mathys, P; Nonclercq, A; (2015) Silicone rubber encapsulation for an endoscopically implantable gastrostimulator. Medical & Biological Engineering & Computing , 53 (4) pp. 319-329. 10.1007/s11517-014-1236-9. Green open access

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Abstract

Gastrointestinal stimulator implants have recently shown positive results in treating obesity. However, the implantation currently requires an invasive surgical procedure. Endoscopy could be used to place the gastric stimulator in the stomach, hence avoiding the riskier surgery. The implant then needs to go through the oesophagus and be located inside the stomach, which imposes new design constraints, such as miniaturization and protecting the electronic circuit against the highly acidic environment of the stomach. We propose to protect the implant by encapsulation with silicone rubber. This paper lists the advantages of this method compared to the more usual approach of a hermetic enclosure and then presents a method to evaluate the underwater adhesive stability of six adhesive/substrate couples, using repeated lap-shear tests and an elevated temperature to accelerate the ageing process. The results for different adhesive/substrate couples tested, presented on probability plots, show that FR4 and alumina substrates with MED4-4220 silicone rubber are suitable for a first implantable prototype. We then compare these with the predicted lifetimes of bonds between historical standard silicone rubber DC3140 and different substrates and describe the encapsulation of our gastrostimulator.

Type: Article
Title: Silicone rubber encapsulation for an endoscopically implantable gastrostimulator
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s11517-014-1236-9
Publisher version: http://dx.doi.org/10.1007/s11517-014-1236-9
Language: English
Additional information: The final publication is available at Springer via http://dx.doi.org/10.1007/s11517-014-1236-9.
Keywords: Compressive Strength, Electric Stimulation, Equipment Failure Analysis, Gastroscopy, Lipids, Materials Testing, Prostheses and Implants, Prosthesis Design, Silicone Elastomers
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/1460464
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