Verhoef, T;
Redekop, WK;
de Boer, A;
Maitland-van der Zee, AH;
(2015)
Economic evaluation of a pharmacogenetic dosing algorithm for coumarin anticoagulants in The Netherlands.
Pharmacogenomics
, 16
(2)
pp. 101-114.
10.2217/pgs.14.149..
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Abstract
Aims: to investigate the cost-effectiveness of a pharmacogenetic dosing algorithm versus a clinical dosing algorithm for coumarin anticoagulants in The Netherlands. Materials & methods: A decision-analytic Markov model was used to analyze the cost-effectiveness of pharmacogenetic dosing of phenprocoumon and acenocoumarol versus clinical dosing. Results: Pharmacogenetic dosing increased costs by €33 and QALYs by 0.001. The incremental cost-effectiveness ratios (ICERs) were €28,349 and €24,427 per QALY gained for phenprocoumon and acenocoumarol respectively. At a willingness to pay threshold of €20,000 per QALY, the pharmacogenetic dosing algorithm was not likely to be cost-effective compared to the clinical dosing algorithm. Conclusions: Pharmacogenetic dosing improves health only slightly when compared with clinical dosing. However, availability of low-cost genotyping would make it a cost-effective option.
| Type: | Article |
|---|---|
| Title: | Economic evaluation of a pharmacogenetic dosing algorithm for coumarin anticoagulants in The Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2217/pgs.14.149. |
| Publisher version: | http://dx.doi.org/10.2217/pgs.14.149. |
| Language: | English |
| Additional information: | © 2015 Future Medicine Ltd |
| Keywords: | acenocoumarol, atrial fibrillation, health economics, pharmacogenetics, phenprocoumon |
| UCL classification: | UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Applied Health Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1460052 |
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