Billen, A;
Madrigal, JA;
Strydom, A;
Szydlo, RM;
Switzer, GE;
Shaw, BE;
(2015)
Predonation Health-Related Quality of Life Scores Predict Time to Recovery in Hematopoietic Stem Cell Donors.
Biology of Blood and Marrow Transplantation
, 21
(2)
pp. 350-356.
10.1016/j.bbmt.2014.10.028.
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Abstract
The physical reactions to hematopoietic stem cell donation have been extensively studied, but less is known about factors that predict poorer donation experiences. The aim of this prospective study was to examine demographic and health-related quality of life (HRQOL) factors that might be associated with recovery and side effects. We also described the changes in HRQOL during the donation process. In total, 275 peripheral blood stem cell (PBSC) and 37 bone marrow (BM) consecutive donors completed the SF-36 questionnaire predonation and 4 weeks, and 3 months postdonation. Predonation HRQOL markers were the strongest predictors of time to recovery. Poorer predonation physical health was associated with longer recovery (P = .017) and certain side effects in PBSC donors. Poorer predonation mental health was associated with longer recovery in BM donors (P = .03) and pain after PBSC donation (P = .003). Physical HRQOL scores declined significantly from predonation to 4 weeks postdonation. This was shown both for PBSC and BM donors (P < .001 and P = .009, respectively), but the decline was much greater for BM donors. There was a return to predonation HRQOL values 3 months after donation in both groups with values well above the mean of the general population (P < .001).
| Type: | Article |
|---|---|
| Title: | Predonation Health-Related Quality of Life Scores Predict Time to Recovery in Hematopoietic Stem Cell Donors |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bbmt.2014.10.028 |
| Publisher version: | http://dx.doi.org/10.1016/j.bbmt.2014.10.028 |
| Language: | English |
| Additional information: | Copyright © 2015 American Society for Blood and Marrow Transplantation. This is an Open Access article published under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Bone marrow, Donation experience, Health-related quality of life, Peripheral blood stem cells, Adolescent, Adult, Bone Marrow Transplantation, Convalescence, Female, Hematopoietic Stem Cell Mobilization, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Humans, Male, Mental Health, Middle Aged, Pain, Peripheral Blood Stem Cell Transplantation, Prospective Studies, Quality of Life, Research Design, Surveys and Questionnaires, Time Factors, Tissue Donors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1458504 |
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