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Developmental challenges in HIV infected children-An updated systematic review

Sherr, L; Croome, N; Castaneda, KP; Bradshaw, K; Romero, RH; (2014) Developmental challenges in HIV infected children-An updated systematic review. CHILDREN AND YOUTH SERVICES REVIEW , 45 74 - 89. 10.1016/j.childyouth.2014.03.040. Green open access

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Abstract

Children with HIV infection are at risk of developmental and behavioural challenges. A systematic review in 2009 set out the extent of delay documented in HIV positive children. This study presents an update and re-analysis. Full searches were conducted in Medline, Cochrane Database and PsycINFO, from which reviewers selected abstracts and followed references to provide detailed studies on HIV and cognitive performance in children under 18 to cover the period 2008–2013. The search generated 21 new studies, 17 of which (81%) report some form of cognitive delay for HIV positive children compared to controls. Some domains measured seem to be more affected than others, with mixed evidence on language and executive functioning. The need for more definitive control of variables was highlighted by the environmental factors contributing to behavioural and cognitive outcomes. In conclusion this systematic review confirms the prevalence of cognitive delay in children with HIV and explores the complexity of the issue. The findings suggest the need for internationally agreed monitoring tools and studies which control for known contributing factors. Research for children is needed with a full understanding of developmental challenges, to point the way forward for effective interventions.

Type: Article
Title: Developmental challenges in HIV infected children-An updated systematic review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.childyouth.2014.03.040
Publisher version: http://dx.doi.org/10.1016/j.childyouth.2014.03.040
Additional information: © 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
Keywords: HIV, Children, Cognitive delay, Development, Behavior
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1448189
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