UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Biological and environmental factors associated with the stress response in infancy: the role of attachment and genetics.

Frigerio, A.; (2008) Biological and environmental factors associated with the stress response in infancy: the role of attachment and genetics. Doctoral thesis , University of London. Green open access

[thumbnail of U592817.pdf] Text
U592817.pdf

Download (9MB)

Abstract

The importance of understanding which environmental and biological factors are involved in determining individual differences in physiological response to stress is widely recognized, as the impact of stress on physical and mental health cannot be ignored. Many researchers believe that our ability to cope with stress originates in infancy through the interaction between our experiences and genes. Several studies have shown how attachment relationships as well as some temperamental traits play a significant role in modulating Hypothalamic Pituitary Adrenal (HPA) axis reactivity to the stress of separation from the mother, as indexed by salivary Cortisol. However, no published studies have investigated their effects on Sympathetic Adreno Medulla (SAM) system reactivity, as indexed by salivary alpha amylase which was recently found to be a marker of SAM activity. Moreover, the contribution of genetics in predicting salivary Cortisol and alpha amylase response to stress in infants has not been investigated yet. In the present study, the child-mother attachment relationship, some genetic polymorphisms (DRD4, DRD4/521, COMT and 5-HTT), and temperamental traits were tested as predictors of both physiological markers during the Strange Situation (SS) procedure in an Italian sample of around 70 healthy infants aged 12 to 18 months. HPA and SAM activity was predicted by a larger number of gene x environment interactions in comparison with the number of separate constitutional (genes and temperament) and environmental (attachment patterns) factors. These results help to disentangle the role played by both biological and environmental factors in determining individual differences in stress response in infancy. The results also shed light on the suggestion that HPA and SAM systems are likely to have different characteristic responses to stress and associations with behaviour.

Type: Thesis (Doctoral)
Title: Biological and environmental factors associated with the stress response in infancy: the role of attachment and genetics.
Identifier: PQ ETD:592817
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Thesis digitised by Proquest
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/1445494
Downloads since deposit
204Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item