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The investigation of corpus cavernosum smooth muscle dysfunction in low-flow priapism.

Muneer, A.; (2007) The investigation of corpus cavernosum smooth muscle dysfunction in low-flow priapism. Doctoral thesis , University of London. Green open access

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Prolonged low-flow (ischaemic) priapism results in a progressive alteration of the microenvironment within the corpus cavemosum with the development of hypoxia, acidosis and glucopenia and a reduction in the responsiveness to a-adrenergic receptor agonists. The aim of this study was to investigate the changes in the corporal microenvironment in patients presenting with refractory low-flow priapism and then develop an in vitro model to investigate the effects of hypoxia, acidosis or glucopenia on the tone of the rabbit corpus cavemosum. The recovery of smooth muscle contractility following exposure to these conditions was also investigated. Hypoxia, acidosis or glucopenia alone or in combination showed a sustained and significant reduction in the smooth muscle tone. This was most marked for conditions of hypoxia combined with glucopenia and the combination of hypoxia, acidosis and glucopenia. Reperfusion of tissue strips showed complete recovery of smooth muscle tone for all conditions except when hypoxia and glucopenia were combined or when hypoxia, glucopenia and acidosis were used in combination. Incomplete recovery of tone was not associated with an impairment of nitrergic relaxation responses but was associated with a significant reduction in tissue ATP concentrations and an increase in the number of TUNEL-positive nuclei. This indicates that in the presence of hypoxia, acidosis and glucopenia, failure of conventional a-adrenergic agonists in low-flow priapism is associated with irreversible smooth muscle cell dysfunction which is linked to ATP depletion and smooth muscle cell death.

Type: Thesis (Doctoral)
Title: The investigation of corpus cavernosum smooth muscle dysfunction in low-flow priapism.
Identifier: PQ ETD:592302
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Thesis digitised by ProQuest. Third party copyright material and sensitive information have been removed from the ethesis
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/1444990
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