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C3b/iC3b deposition on Streptococcus pneumoniae is not affected by HIV infection

Hyams, C; Tam, JC; Brown, JS; Gordon, S; (2010) C3b/iC3b deposition on Streptococcus pneumoniae is not affected by HIV infection. PLoS One , 5 (1) , Article e8902. 10.1371/journal.pone.0008902. Green open access

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Abstract

Streptococcus pneumoniae is a common cause of infection in both HIV positive patients and those with complement deficiencies. We hypothesised that HIV positive individuals might exhibit reduced opsonisation of pneumococcus with complement due to reduced levels of S. pneumoniae specific IgG. We discovered no difference in C3 deposition on S. pneumoniae between HIV positive or negative individuals, and furthermore C3 deposition remained unchanged as HIV progressed towards AIDS. We found no correlation between C3 deposition on S. pneumoniae and CD4 cell count in HIV infected individuals. Hence we have demonstrated no failure of complement immunity in HIV positive patients.

Type: Article
Title: C3b/iC3b deposition on Streptococcus pneumoniae is not affected by HIV infection
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0008902
Publisher version: http://dx.doi.org/10.1371/journal.pone.0008902
Language: English
Additional information: © 2010 Hyams et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: CH is supported by the Astor Foundation and Glaxo Smith Kline through the University College London MB PhD programme. SGB is supported by the Wellcome Trust (grant 061231). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/144431
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