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Ethical considerations in determining standard of prevention packages for HIV prevention trials: Examining PrEP

Haire, B; Folayan, MO; Hankins, C; Sugarman, J; McCormack, S; Ramjee, G; Warren, M; (2013) Ethical considerations in determining standard of prevention packages for HIV prevention trials: Examining PrEP. Developing World Bioethics , 13 (2) 87 - 94. 10.1111/dewb.12032. Green open access

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Abstract

The successful demonstration that antiretroviral (ARV) drugs can be used in diverse ways to reduce HIV acquisition or transmission risks – either taken as pre-exposure prophylaxis (PrEP) by those who are uninfected or as early treatment for prevention (T4P) by those living with HIV – expands the armamentarium of existing HIV prevention tools. These findings have implications for the design of future HIV prevention research trials. With the advent of multiple effective HIV prevention tools, discussions about the ethics and the feasibility of future HIV prevention trial designs have intensified. This article outlines arguments concerning the inclusion of newly established ARV-based HIV prevention interventions as standard of prevention in HIV prevention trials from multiple perspectives. Ultimately, there is a clear need to incorporate stakeholders in a robust discussion to determine the appropriate trial design for each study population.

Type: Article
Title: Ethical considerations in determining standard of prevention packages for HIV prevention trials: Examining PrEP
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/dewb.12032
Publisher version: http://dx.doi.org/10.1111/dewb.12032
Language: English
Additional information: © 2013 The Authors. Developing World Bioethics published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Antiretroviral therapy, HIV/AIDS, Research ethics, Developing world bioethics, Guidelines, International justice
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1443245
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