UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Electrophysiological correlates of the BOLD signal for EEG-informed fMRI

Gonçalves Murta, TI; Leite, M; Carmichael, DW; Figueiredo, P; Lemieux, L; (2014) Electrophysiological correlates of the BOLD signal for EEG-informed fMRI. Human Brain Mapping , 36 (1) pp. 391-414. 10.1002/hbm.22623. Green open access

[thumbnail of hbm22623.pdf] PDF
hbm22623.pdf

Download (496kB)

Abstract

EEG and fMRI are important tools in cognitive and clinical neuroscience. Combined EEGfMRI has been shown to help to characterise brain networks involved in epileptic activity, as well as in different sensory, motor and cognitive functions. A good understanding of the electrophysiological correlates of the blood oxygen level dependent (BOLD) signal is necessary to interpret fMRI maps, particularly when obtained in combination with EEG. We review the current understanding of electrophysiological-haemodynamic correlates, during different types of brain activity. We start by describing the basic mechanisms underlying EEG and BOLD signals, and proceed by reviewing EEG-informed fMRI studies using fMRI to map specific EEG phenomena over the entire brain (“EEG-fMRI mapping”), or exploring a range of EEGderived quantities to determine which best explain co-localised BOLD fluctuations (“local EEG-fMRI coupling”). While reviewing studies of different forms of brain activity (epileptic and non-epileptic spontaneous activity; cognitive, sensory and motor functions), a significant attention is given to epilepsy because the investigation of its haemodynamic correlates is the most common application of EEG-informed fMRI. Our review is focused on EEG-informed fMRI, an asymmetric approach of data integration. We give special attention to the invasiveness of electrophysiological measurements and the simultaneity of multimodal acquisitions because these methodological aspects determine the nature of the conclusions that can be drawn from EEG-informed fMRI studies. We emphasise the advantages of, and need for, simultaneous intracranial EEG-fMRI studies in humans, which recently became available and hold great potential to improve our understanding of the electrophysiological correlates of BOLD fluctuations.

Type: Article
Title: Electrophysiological correlates of the BOLD signal for EEG-informed fMRI
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/hbm.22623
Publisher version: http://dx.doi.org/10.1002/hbm.22623
Language: English
Additional information: © 2014 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
URI: https://discovery.ucl.ac.uk/id/eprint/1443170
Downloads since deposit
196Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item