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Synaptically induced long-term modulation of electrical coupling in the inferior olive.

Mathy, A; Clark, BA; Häusser, M; (2014) Synaptically induced long-term modulation of electrical coupling in the inferior olive. Neuron , 81 (6) 1290 - 1296. 10.1016/j.neuron.2014.01.005. Green open access

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Abstract

Electrical coupling mediated by gap junctions is widespread in the mammalian CNS, and the interplay between chemical and electrical synapses on the millisecond timescale is crucial for determining patterns of synchrony in many neural circuits. Here we show that activation of glutamatergic synapses drives long-term depression of electrical coupling between neurons of the inferior olive. We demonstrate that this plasticity is not triggered by postsynaptic spiking alone and that it requires calcium entry following synaptic NMDA receptor activation. These results reveal that glutamatergic synapses can instruct plasticity at electrical synapses, providing a means for excitatory inputs to homeostatically regulate the long-term dynamics of microzones in olivocerebellar circuits.

Type: Article
Title: Synaptically induced long-term modulation of electrical coupling in the inferior olive.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2014.01.005
Publisher version: http://dx.doi.org/10.1016/j.neuron.2014.01.005
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
Keywords: Animals, Excitatory Postsynaptic Potentials, Gap Junctions, Long-Term Synaptic Depression, Neuronal Plasticity, Neurons, Olivary Nucleus, Rats, Synapses, Synaptic Transmission
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/1431718
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