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The Effects of School Closures on Influenza Outbreaks and Pandemics: Systematic Review of Simulation Studies

Jackson, C; Mangtani, P; Hawker, J; Olowokure, B; Vynnycky, E; (2014) The Effects of School Closures on Influenza Outbreaks and Pandemics: Systematic Review of Simulation Studies. PLoS ONE , 9 (5) , Article e97297. 10.1371/journal.pone.0097297. Green open access

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Abstract

<sec> <title>Background</title> <p>School closure is a potential intervention during an influenza pandemic and has been investigated in many modelling studies.</p> </sec><sec> <title>Objectives</title> <p>To systematically review the effects of school closure on influenza outbreaks as predicted by simulation studies.</p> </sec><sec> <title>Methods</title> <p>We searched Medline and Embase for relevant modelling studies published by the end of October 2012, and handsearched key journals. We summarised the predicted effects of school closure on the peak and cumulative attack rates and the duration of the epidemic. We investigated how these predictions depended on the basic reproduction number, the timing and duration of closure and the assumed effects of school closures on contact patterns.</p> </sec><sec> <title>Results</title> <p>School closures were usually predicted to be most effective if they caused large reductions in contact, if transmissibility was low (e.g. a basic reproduction number &lt;2), and if attack rates were higher in children than in adults. The cumulative attack rate was expected to change less than the peak, but quantitative predictions varied (e.g. reductions in the peak were frequently 20–60% but some studies predicted &gt;90% reductions or even increases under certain assumptions). This partly reflected differences in model assumptions, such as those regarding population contact patterns.</p> </sec><sec> <title>Conclusions</title> <p>Simulation studies suggest that school closure can be a useful control measure during an influenza pandemic, particularly for reducing peak demand on health services. However, it is difficult to accurately quantify the likely benefits. Further studies of the effects of reactive school closures on contact patterns are needed to improve the accuracy of model predictions.</p> </sec>

Type: Article
Title: The Effects of School Closures on Influenza Outbreaks and Pandemics: Systematic Review of Simulation Studies
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0097297
Publisher version: http://dx.doi.org/10.1371/journal.pone.0097297
Additional information: �© 2014 Jackson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1431611
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