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Characterisation of phosphate coacervates for potential biomedical applications

Pickup, DM; Newport, RJ; Barney, ER; Kim, J-Y; Valappil, SP; Knowles, JC; (2014) Characterisation of phosphate coacervates for potential biomedical applications. Journal of Biomaterials Applications , 28 (8) 1226 - 1234. 10.1177/0885328213502586. Green open access

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Abstract

In this study, amorphous (Na2O) x (CaO)0.50− x (P2O5)0.50·yH2O (where x = ∼0.15 and y = ∼3) samples were prepared by a coacervate method. Thermal analysis showed that two types of water molecules were present in the coacervate structures: one type loosely bound and the other part of the phosphate structure. Structural studies using Fourier transform infrared spectroscopy (FTIR) and X-ray total diffraction revealed the samples to have very similar structures to melt-quenched glasses of comparable composition. Furthermore, no significant structural differences were observed between samples prepared using calcium nitrate as the calcium source or those prepared from calcium chloride. A sample containing ∼1 mol% Ag2O was prepared to test the hypothesis that calcium phosphate coacervate materials could be used as delivery agents for antibacterial ions. This sample exhibited significant antibacterial activity against the bacterium Psuedomonas aeruginosa. FTIR data revealed the silver-doped sample to be structurally akin to the analogous silver-free sample.

Type: Article
Title: Characterisation of phosphate coacervates for potential biomedical applications
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0885328213502586
Publisher version: http://dx.doi.org/10.1177/0885328213502586
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm). PubMed ID: 24045415
Keywords: X-ray total diffraction, biomaterials, phosphate glasses, antibacterial, FTIR, Coacervates
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1427848
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