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Tailoring Cell Behavior on Polymers by the Incorporation of Titanium Doped Phosphate Glass Filler

Chrzanowski, W; Abou Neel, EA; Lee, KY; Bismarck, A; Young, AM; Hart, AD; Dalby, MJ; (2010) Tailoring Cell Behavior on Polymers by the Incorporation of Titanium Doped Phosphate Glass Filler. ADVANCED ENGINEERING MATERIALS , 12 (7) B298 - B308. 10.1002/adem.200980083. Green open access

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Abstract

Understanding tissue response to materials, to enable modulation and guided tissue regeneration is one of the main challenges in biomaterials science. Nowadays polymers, glasses, and metals dominate as biomaterials. Often native properties of those materials are not sufficient and there is a need to combine them, so as to modify and adjust their properties to the application. The primary aim of this study was to improve cell response to polymer (PLDL) using phosphate glass as filler (titanium doped phosphate glass). As a control beta-tricalcium phosphate (TCP) filler was used. Various concentrations of the filler were used (10-40 vol%). Wetting behavior, zeta-potentials, mechanical and thermal properties, and human cells response to the materials were evaluated. Results showed that with increase in glass filler loading wettability improved, zeta-potentials dropped, and increase in stiffness of materials was observed. Importantly cell culture experiments showed more developed and well spread cells on the samples with glass content up to 20 vol%. Cells responded much more positively to the glass filled samples than to TCP filled. However, expression of osteocalcin and osteopontin, proteins that indicate formation of the mineralized structures was positive for all the samples including pure PLDL. It was concluded that due to improved wetting behavior, lower zeta-potentials, and specific chemistry of the glass filler it was possible to alter cells response, improve bioactivity of the polymer, and vary mechanical properties.

Type: Article
Title: Tailoring Cell Behavior on Polymers by the Incorporation of Titanium Doped Phosphate Glass Filler
Location: Glasgow, SCOTLAND
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/adem.200980083
Publisher version: http://dx.doi.org/10.1002/adem.200980083
Additional information: �© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Full text made available to UCL Discovery by kind permission of Wiley.
Keywords: HYDROXYAPATITE COMPOSITES, BIODEGRADABLE POLYMERS, IN-VITRO, SCAFFOLDS, BIOCOMPATIBILITY, SURFACE, RELEASE, BIOMATERIALS, BIOACTIVITY, CERAMICS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
URI: https://discovery.ucl.ac.uk/id/eprint/142546
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