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The influence of puberty on subcortical brain development

Goddings, AL; Mills, KL; Clasen, LS; Giedd, JN; Viner, RM; Blakemore, SJ; (2014) The influence of puberty on subcortical brain development. Neuroimage , 88 pp. 242-251. 10.1016/j.neuroimage.2013.09.073. Green open access

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Abstract

Puberty is characterized by hormonal, physical and psychological transformation. The human brain undergoes significant changes between childhood and adulthood, but little is known about how puberty influences its structural development. Using a longitudinal sample of 711 magnetic resonance imaging scans from 275 individuals aged 7-20years, we examined how subcortical brain regions change in relation to puberty. Our regions of interest included the amygdala, hippocampus and corpus striatum including the nucleus accumbens (NA), caudate, putamen and globus pallidus (GP). Pubertal development was significantly related to structural volume in all six regions in both sexes. Pubertal development and age had both independent and interactive influences on volume for the amygdala, hippocampus and putamen in both sexes, and the caudate in females. There was an interactive puberty-by-age effect on volume for the NA and GP in both sexes, and the caudate in males. These findings suggest a significant role for puberty in structural brain development.

Type: Article
Title: The influence of puberty on subcortical brain development
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuroimage.2013.09.073
Publisher version: http://dx.doi.org/10.1016/j.neuroimage.2013.09.073
Language: English
Additional information: Available for re-use under the terms of a CC-BY-NC-ND licence: http://creativecommons.org/licenses/by-nc-nd/3.0/
Keywords: Adolescence, MRI, Puberty, Subcortex, Adolescent, Adolescent Development, Amygdala, Brain, Child, Corpus Striatum, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Nucleus Accumbens, Puberty
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1423374
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