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Diffusion microscopic MRI of the mouse embryo: Protocol and practical implementation in the splotch mouse model

Norris, FC; Siow, BM; Cleary, JO; Wells, JA; De Castro, SC; Ordidge, RJ; Greene, ND; ... Lythgoe, MF; + view all (2015) Diffusion microscopic MRI of the mouse embryo: Protocol and practical implementation in the splotch mouse model. Magnetic Resonance in Medicine , 73 (2) 731 - 739. 10.1002/mrm.25145. Green open access

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Abstract

Advanced methodologies for visualizing novel tissue contrast are essential for phenotyping the ever-increasing number of mutant mouse embryos being generated. Although diffusion microscopic MRI (μMRI) has been used to phenotype embryos, widespread routine use is limited by extended scanning times, and there is no established experimental procedure ensuring optimal data acquisition.

Type: Article
Title: Diffusion microscopic MRI of the mouse embryo: Protocol and practical implementation in the splotch mouse model
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mrm.25145
Publisher version: http://dx.doi.org/10.1002/mrm.25145
Language: English
Additional information: © 2014 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: diffusion microscopic magnetic resonance imaging, mouse embryo, phenotyping, spina bifida, splotch mouse model
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/1422757
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