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Inflammation-based scores do not predict post-transplant recurrence of hepatocellular carcinoma (HCC) in patients within Milan criteria.

Parisi, I; Tsochatzis, E; Wijewantha, H; Rodríguez-Perálvarez, M; De Luca, L; Manousou, P; Fatourou, E; ... Burroughs, AK; + view all (2014) Inflammation-based scores do not predict post-transplant recurrence of hepatocellular carcinoma (HCC) in patients within Milan criteria. Liver Transplantation , 20 (11) pp. 1327-1335. 10.1002/lt.23969. Green open access

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Abstract

Background: Increased preoperative inflammation scores, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and inflammation-based index (IBI) have been related to post-transplant HCC recurrence. We evaluated the association between inflammation-based scores (NLR, PLR, IBI) and post-LT HCC recurrence as well as tumour necrosis after transarterial embolisation. Methods: 150 consecutive patients that were transplanted for HCC within the Milan criteria between 1996-2010 were included; data regarding inflammatory markers, patient and tumour characteristics were analyzed. Results: NLR, PLR and IBI were not significantly associated with post-LT HCC recurrence or worse overall survival. Increased NLR and PLR were associated with complete tumour necrosis in the subset of patients that received preoperative transarterial embolization (P<0.05). Cox regression analysis revealed that absence of neo-adjuvant transarterial therapy (OR=4.33, 95%CI 1.28-14.64; P=0.02) and no fulfilment of the Milan criteria in the explanted liver (OR=3.34, 95%CI 1.08-10.35; P=0.04) were independently associated with post-LT HCC recurrence. Conclusion: Inflammation-based scores did not predict HCC recurrence post-LT in our group of patients. NLR and PLR were associated with better response to TAE, as this was recorded histologically in the explanted liver. Histological fulfilment of the Milan criteria and absence of neo-adjuvant transarterial treatment were significantly associated with post-LT HCC recurrence. Liver Transpl , 2014. © 2014 AASLD.

Type: Article
Title: Inflammation-based scores do not predict post-transplant recurrence of hepatocellular carcinoma (HCC) in patients within Milan criteria.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/lt.23969
Publisher version: http://dx.doi.org/10.1002/lt.23969
Language: English
Additional information: Contacted OA Team and confirmed that article licenced under a CC BY NC ND licence.
Keywords: Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, prognosis, transarterial embolization
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/1421094
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