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Revealing Individual Signatures of Human T Cell CDR3 Sequence Repertoires with Kidera Factors.

Epstein, M; Barenco, M; Klein, N; Hubank, M; Callard, RE; (2014) Revealing Individual Signatures of Human T Cell CDR3 Sequence Repertoires with Kidera Factors. PLoS One , 9 (1) , Article e86986. 10.1371/journal.pone.0086986. Green open access

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Abstract

The recent development of High Throughput Sequencing technologies has enabled an individual's TCR repertoire to be efficiently analysed at the nucleotide level. However, with unique clonotypes ranging in the tens of millions per individual, this approach gives a surfeit of information that is difficult to analyse and interpret in a biological context and gives little information about TCR structural diversity. Using publicly available TCR CDR3 sequence data, we analysed TCR repertoires by converting the encoded CDR3 amino acid sequences into Kidera Factors, a set of orthogonal physico-chemical properties that reflect protein structure. This approach enabled the TCR repertoire from different individuals to be distinguished and demonstrated the close similarity of the repertoire in different samples from the same individual.

Type: Article
Title: Revealing Individual Signatures of Human T Cell CDR3 Sequence Repertoires with Kidera Factors.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0086986
Publisher version: http://dx.doi.org/10.1371/journal.pone.0086986
Language: English
Additional information: © 2014 Epstein et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3906109
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1419333
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