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Coherent x-ray imaging of collagen fibril distributions within intact tendons

Berenguer, F; Bean, RJ; Bozec, L; Vila-Comamala, J; Zhang, F; Kewish, CM; Bunk, O; ... Robinson, IK; + view all (2014) Coherent x-ray imaging of collagen fibril distributions within intact tendons. Biophysical Journal , 106 (2) 459 - 466. 10.1016/j.bpj.2013.12.016. Green open access

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Abstract

The characterization of the structure of highly hierarchical biosamples such as collagen-based tissues at the scale of tens of nanometers is essential to correlate the tissue structure with its growth processes. Coherent x-ray Bragg ptychography is an innovative imaging technique that gives high resolution images of the ordered parts of such samples. Herein, we report how we used this method to image the collagen fibrillar ultrastructure of intact rat tail tendons. The images show ordered fibrils extending over 10-20 μm in length, with a quantifiable D-banding spacing variation of 0.2%. Occasional defects in the fibrils distribution have also been observed, likely indicating fibrillar fusion events.

Type: Article
Title: Coherent x-ray imaging of collagen fibril distributions within intact tendons
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bpj.2013.12.016
Publisher version: http://dx.doi.org/10.1016/j.bpj.2013.12.016
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons-Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/2.0/), which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3907247
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1419068
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