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A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking

Teunissen, CE; Petzold, A; Bennett, JL; Berven, FS; Brundin, L; Comabella, M; Franciotta, D; ... Deisenhammer, F; + view all (2009) A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking. Neurology , 73 (22) 1914 - 1922. 10.1212/WNL.0b013e3181c47cc2. Green open access

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Abstract

There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in CSF are being used in clinical practice. One of the most critical factors in CSF biomarker research is the inadequate powering of studies because of the lack of sufficient samples that can be obtained in single-center studies. Therefore, collaboration between investigators is needed to establish large biobanks of well-defined samples. Standardized protocols for biobanking are a prerequisite to ensure that the statistical power gained by increasing the numbers of CSF samples is not compromised by preanalytical factors. Here, a consensus report on recommendations for CSF collection and biobanking is presented, formed by the BioMS-eu network for CSF biomarker research in multiple sclerosis. We focus on CSF collection procedures, preanalytical factors, and high-quality clinical and paraclinical information. The biobanking protocols are applicable for CSF biobanks for research targeting any neurologic disease. Neurology (R) 2009; 73: 1914-1922

Type: Article
Title: A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking
Open access status: An open access version is available from UCL Discovery
DOI: 10.1212/WNL.0b013e3181c47cc2
Publisher version: https://doi.org/10.1212/WNL.0b013e3181c47cc2
Language: English
Additional information: This version is version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: MULTIPLE-SCLEROSIS PATIENTS, AMYLOID-BETA PEPTIDES, STATUS SCALE EDSS, LUMBAR PUNCTURE, DIAGNOSTIC-CRITERIA, MASS-SPECTROMETRY, DISABILITY, DISEASE, BLOOD, SERUM
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/141850
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