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Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions

Muhlert, N; Atzori, M; De Vita, E; Thomas, DL; Samson, RS; Wheeler-Kingshott, CA; Geurts, JJ; ... Ciccarelli, O; + view all (2014) Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions. Journal of Neurology, Neurosurgery and Psychiatry , 85 (8) pp. 833-839. 10.1136/jnnp-2013-306662. Green open access

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Abstract

Glutamate is the principal excitatory neurotransmitter and is involved in normal brain function. Cognitive impairment is common in multiple sclerosis (MS), and understanding its mechanisms is crucial for developing effective treatments. We used structural and metabolic brain imaging to test two hypotheses: (i) glutamate levels in grey matter regions are abnormal in MS, and (ii) patients show a relationship between glutamate concentration and memory performance.

Type: Article
Title: Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/jnnp-2013-306662
Publisher version: http://dx.doi.org/10.1136/jnnp-2013-306662
Language: English
Additional information: This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/ by/3.0/
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1418221
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