Muhlert, N;
Atzori, M;
De Vita, E;
Thomas, DL;
Samson, RS;
Wheeler-Kingshott, CA;
Geurts, JJ;
... Ciccarelli, O; + view all
(2014)
Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions.
Journal of Neurology, Neurosurgery and Psychiatry
, 85
(8)
pp. 833-839.
10.1136/jnnp-2013-306662.
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Abstract
Glutamate is the principal excitatory neurotransmitter and is involved in normal brain function. Cognitive impairment is common in multiple sclerosis (MS), and understanding its mechanisms is crucial for developing effective treatments. We used structural and metabolic brain imaging to test two hypotheses: (i) glutamate levels in grey matter regions are abnormal in MS, and (ii) patients show a relationship between glutamate concentration and memory performance.
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