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Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography

Dayan, M; Munoz, M; Jentschke, S; Chadwick, MJ; Cooper, JM; Riney, K; Vargha-Khadem, F; (2015) Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography. Brain Struct Funct , 220 (1) 291 - 306. 10.1007/s00429-013-0655-y. Green open access

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Abstract

The optic radiation (OR) is a component of the visual system known to be myelin mature very early in life. Diffusion tensor imaging (DTI) and its unique ability to reconstruct the OR in vivo were used to study structural maturation through analysis of DTI metrics in a cohort of 90 children aged 5-18 years. As the OR is at risk of damage during epilepsy surgery, we measured its position relative to characteristic anatomical landmarks. Anatomical distances, DTI metrics and volume of the OR were investigated for age, gender and hemisphere effects. We observed changes in DTI metrics with age comparable to known trajectories in other white matter tracts. Left lateralization of DTI metrics was observed that showed a gender effect in lateralization. Sexual dimorphism of DTI metrics in the right hemisphere was also found. With respect to OR dimensions, volume was shown to be right lateralised and sexual dimorphism demonstrated for the extent of the left OR. The anatomical results presented for the OR have potentially important applications for neurosurgical planning.

Type: Article
Title: Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00429-013-0655-y
Publisher version: http:dx.doi.org/10.1007/s00429-013-0655-y
Language: English
Additional information: © The Author(s) 2013. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1408627
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