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Lifetime affect and midlife cognitive function: prospective birth cohort study

Richards, M; Barnett, JH; Xu, MK; Croudace, TJ; Gaysina, D; Kuh, D; Jones, PB; (2014) Lifetime affect and midlife cognitive function: prospective birth cohort study. British Journal of Psychiatry , 204 (3) pp. 194-199. 10.1192/bjp.bp.113.128942. Green open access

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Abstract

Background: Recurrent affective problems are predictive of cognitive impairment, but the timing and directionality, and the nature of the cognitive impairment, are unclear. / Aims: To test prospective associations between life-course affective symptoms and cognitive function in late middle age. / Method: A total of 1668 men and women were drawn from the Medical Research Council National Survey of Health and Development (the British 1946 birth cohort). Longitudinal affective symptoms spanning age 13-53 years served as predictors; outcomes consisted of self-reported memory problems at 60-64 years and decline in memory and information processing from age 53 to 60-64 years. / Results: Regression analyses revealed no clear pattern of association between longitudinal affective symptoms and decline in cognitive test scores, after adjusting for gender, childhood cognitive ability, education and midlife socioeconomic status. In contrast, affective symptoms were strongly, diffusely and independently associated with self-reported memory problems. / Conclusions: Affective symptoms are more clearly associated with self-reported memory problems in late midlife than with objectively measured cognitive performance.

Type: Article
Title: Lifetime affect and midlife cognitive function: prospective birth cohort study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1192/bjp.bp.113.128942
Publisher version: http://dx.doi.org/10.1192/bjp.bp.113.128942
Language: English
Additional information: Copyright © Royal College of Psychiatrists 2013. This paper accords with the Wellcome Trust Open Access policy and is governed by the licence available at: http://www.rcpsych.ac.uk/pdf/Wellcome%20Trust%20licence.pdf
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
URI: https://discovery.ucl.ac.uk/id/eprint/1406606
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