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Miniature bioreactors: current practices and future opportunities

Betts, JI; Baganz, F; (2006) Miniature bioreactors: current practices and future opportunities. [Review]. Microbial Cell Factories , 5 , Article 21. 10.1186/1475-2859-5-21. Green open access

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Abstract

This review focuses on the emerging field of miniature bioreactors (MBRs), and examines the way in which they are used to speed up many areas of bioprocessing. MBRs aim to achieve this acceleration as a result of their inherent high-throughput capability, which results from their ability to perform many cell cultivations in parallel. There are several applications for MBRs, ranging from media development and strain improvement to process optimisation. The potential of MBRs for use in these applications will be explained in detail in this review. MBRs are currently based on several existing bioreactor platforms such as shaken devices, stirred-tank reactors and bubble columns. This review will present the advantages and disadvantages of each design together with an appraisal of prototype and commercialised devices developed for parallel operation. Finally we will discuss how MBRs can be used in conjunction with automated robotic systems and other miniature process units to deliver a fully-integrated, high-throughput (HT) solution for cell cultivation process development.

Type: Article
Title: Miniature bioreactors: current practices and future opportunities
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1475-2859-5-21
Publisher version: http://dx.doi.org/10.1186/1475-2859-5-21
Language: English
Additional information: © 2006 Betts and Baganz; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Microbial process-development, throughput bioprocess design, liquid mass-transfer, small-scale, microtiter plates, oxygen-transfer, escherichia-coli, shake-flasks, hybridoma cells, bubble-columns
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/140453
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