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Duration of the IgM response in women acquiring Toxoplasma gondii during pregnancy: implications for clinical practice and cross-sectional incidence studies

Gras, L; Gilbert, RE; Wallon, M; Peyron, F; Cortina-Borja, M; (2004) Duration of the IgM response in women acquiring Toxoplasma gondii during pregnancy: implications for clinical practice and cross-sectional incidence studies. EPIDEMIOL INFECT , 132 (3) 541 - 548. 10.1017/S0950268803001948. Green open access

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Abstract

We followed up a cohort of 446 toxoplasma-infected pregnant women to determine the median and variability of the duration of positive toxoplasma-IgM (immunoglobulin M) results measured by an immunofluorescence test (IFT) and an immunosorbent agglutination assay (ISAGA). IgM antibodies were detected for longer using the ISAGA test [median 12(.)8 months, interquartile range (IQR) 6(.)9-24(.)9] than the IFT (median 10(.)4, IQR 7(.)1-14(.)4), but the variability between individuals in the duration of IgM positivity was greatest for the ISAGA test. IgM-positive results persisted beyond 2 years in a substantial minority of women (27(.)1% ISAGA, 9(.)1% IFT). Variation in the duration of the IgM response measured by ISAGA and IFT limit their usefulness for predicting the timing of infection in pregnant women. However, measurement of IgM and IgG antibodies in a cross-sectional serosurvey offers an efficient method for estimating the incidence of toxoplasma infection.

Type: Article
Title: Duration of the IgM response in women acquiring Toxoplasma gondii during pregnancy: implications for clinical practice and cross-sectional incidence studies
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0950268803001948
Publisher version: http://dx.doi.org/10.1017/S0950268803001948
Language: English
Additional information: © 2004 Cambridge University Press
Keywords: TO-CHILD TRANSMISSION, DOUBLY CENSORED-DATA, IMMUNOGLOBULIN-M, INFECTION, SEROPREVALENCE, ANTIBODIES, DISEASES, HORMONES, ASSAY, AIDS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/139742
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