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Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8

Nassar, MA; Levato, A; Stirling, LC; Wood, JN; (2005) Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8. Molecular Pain , 1 , Article 24. 10.1186/1744-8069-1-24. Green open access

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Abstract

Two voltage gated sodium channel alpha-subunits, Na(v)1.7 and Na(v)1.8, are expressed at high levels in nociceptor terminals and have been implicated in the development of inflammatory pain. Misexpression of voltage-gated sodium channels by damaged sensory neurons has also been implicated in the development of neuropathic pain, but the role of Na(v)1.7 and Na(v)1.8 is uncertain. Here we show that deleting Na(v)1.7 has no effect on the development of neuropathic pain. Double knockouts of both Na(v)1.7 and Na(v)1.8 also develop normal levels of neuropathic pain, despite a lack of inflammatory pain symptoms and altered mechanical and thermal acute pain thresholds. These studies demonstrate that, in contrast to the highly significant role for Na(v)1.7 in determining inflammatory pain thresholds, the development of neuropathic pain does not require the presence of either Na(v)1.7 or Na(v)1.8 alone or in combination.

Type: Article
Title: Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1744-8069-1-24
Publisher version: http://dx.doi.org/10.1186/1744-8069-1-24
Language: English
Additional information: © 2005 Nassar et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Resistant sodium-channel, dorsal-root ganglia, sensory neurons, alpha-subunit, rat, expression, pn1, hyperalgesia, involvement, mutations
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/139710
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