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Axon radius estimation with Oscillating Gradient Spin Echo (OGSE) Diffusion MRI

Siow, BMCW; Drobnjak, I; Ianus, A; Christie, IN; Lythgoe, MF; Alexander, DC; (2013) Axon radius estimation with Oscillating Gradient Spin Echo (OGSE) Diffusion MRI. Diffusion Fundamentals , 18 (1) 1 - 6. Green open access

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Abstract

The estimation of axon radius provides insights into brain function and could provide progression and classification biomarkers for a number of white matter diseases. A recent in silico study has shown that optimised gradient waveforms (GEN) and oscillating gradient waveform spin echo (OGSE) have increased sensitivity to small axon radius compared to pulsed gradient spin echo (PGSE) diffusion MR sequences. In a follow-up study, experiments with glass capillaries show the practical feasibility of GEN sequences and verify improved pore-size estimates. Here, we compare PGSE with sine, sine with arbitrary phase, and square wave OGSE (SNOGSE, SPOGSE, SWOGSE, respectively) for axon radius mapping in the corpus callosum of a rat, ex-vivo. Our results suggest improvements in pore size estimates from OGSE over PGSE, with greatest improvement from SWOGSE, supporting theoretical results from and other studies.

Type: Article
Title: Axon radius estimation with Oscillating Gradient Spin Echo (OGSE) Diffusion MRI
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.uni-leipzig.de/diffusion/pdf/volume18/d...
Additional information: © 2013 Bernard Siow. Deposited in UCL Discovery with permission from the journal.
Keywords: Axon diameter, diffusion MR, oscillating gradient spin echo, optimised gradient waveform, ActiveAx
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/1396458
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