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Responses of primate LGN cells to moving stimuli involve a constant background modulation by feedback from area MT

Jones, HE; Andolina, IM; Grieve, KL; Wang, W; Salt, TE; Cudeiro, J; Sillito, AM; (2013) Responses of primate LGN cells to moving stimuli involve a constant background modulation by feedback from area MT. Neuroscience , 246 pp. 254-264. 10.1016/j.neuroscience.2013.04.055. Green open access

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Abstract

The feedback connections from the cortical motion area middle temporal (MT), to layer 6 of the primary visual cortex (V1), have the capacity to drive a cascaded feedback influence from the layer 6 cortico-geniculate cells back to the lateral geniculate nucleus (LGN) relay cells. This introduces the possibility of a re-entrant motion signal affecting the relay of the retinal input through the LGN to the visual cortex. The question is whether the response of LGN cells to moving stimuli involves a component derived from this feedback. By producing a reversible focal pharmacological block of the activity of an MT direction column we show the presence of such an influence from MT on the responses of magno, parvo and koniocellular cells in the macaque LGN. The pattern of effect in the LGN reflects the direction bias of the MT location inactivated. This suggests a moving stimulus is captured by iterative interactions in the circuit formed by visual cortical areas and visual thalamus.

Type: Article
Title: Responses of primate LGN cells to moving stimuli involve a constant background modulation by feedback from area MT
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuroscience.2013.04.055
Publisher version: http://dx.doi.org/10.1016/j.neuroscience.2013.04.0...
Language: English
Additional information: This work is licensed under the Creative Commons Attribution License, Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/ which permits unrestricted use, distribution, and reproduction in any medium. However, you must attribute the work to the author (but not in any way that suggests that they endorse you or your use of the work).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1393716
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