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Novel exomphalos genetic mouse model: The importance of accurate phenotypic classification.

Carnaghan, H; Roberts, T; Savery, D; Norris, FC; McCann, CJ; Copp, AJ; Scambler, PJ; ... Eaton, S; + view all (2013) Novel exomphalos genetic mouse model: The importance of accurate phenotypic classification. J Pediatr Surg , 48 (10) 2036 - 2042. 10.1016/j.jpedsurg.2013.04.010. Green open access

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Abstract

Rodent models of abdominal wall defects (AWD) may provide insight into the pathophysiology of these conditions including gut dysfunction in gastroschisis, or pulmonary hypoplasia in exomphalos. Previously, a Scribble mutant mouse model (circletail) was reported to exhibit gastroschisis. We further characterise this AWD in Scribble knockout mice.

Type: Article
Title: Novel exomphalos genetic mouse model: The importance of accurate phenotypic classification.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jpedsurg.2013.04.010
Publisher version: http://dx.doi.org/10.1016/j.jpedsurg.2013.04.010
Language: English
Additional information: © 2013 Elsevier Inc. Open access under CC BY license.
Keywords: Abdominal wall defect, Exomphalos, Gastroschisis, In amnio micro-MRI, Interstitial cells of Cajal, Rodent model, Scrib
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1393441
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