UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Thermodynamics of heat-shock response

Arnvig, KB; Pedersen, S; Sneppen, K; (2000) Thermodynamics of heat-shock response. Physical Review Letters , 84 (13) pp. 3005-3008. 10.1103/PhysRevLett.84.3005. Green open access

[thumbnail of 1393270.pdf]
Preview
PDF
1393270.pdf

Download (59kB)

Abstract

Production of heat-shock proteins is induced when a living cell is exposed to a rise in temperature. The heat-shock response of protein DnaK synthesis in E.coli for temperature shifts T → T + ΔT and T → T - ΔT is measured as a function of the initial temperature T. We observe a reversed heat shock at low T. The magnitude of the shock increases when one increases the distance to the temperature T ≈ 23 °C, thereby mimicking the nonmonotonous stability of proteins at low temperature. This suggests that stability related to hot as well as cold unfolding of proteins is directly implemented in the biological control of protein folding. © 2000 The American Physical Society.

Type: Article
Title: Thermodynamics of heat-shock response
Open access status: An open access version is available from UCL Discovery
DOI: 10.1103/PhysRevLett.84.3005
Publisher version: http://dx.doi.org/10.1103/PhysRevLett.84.3005
Language: English
Additional information: © 2000 The American Physical Society
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1393270
Downloads since deposit
95Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item