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Transcriptional Instability during Evolving Sepsis May Limit Biomarker Based Risk Stratification.

Kwan, A; Hubank, M; Rashid, A; Klein, N; Peters, MJ; (2013) Transcriptional Instability during Evolving Sepsis May Limit Biomarker Based Risk Stratification. PLoS One , 8 (3) , Article e60501. 10.1371/journal.pone.0060501. Green open access

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Abstract

Sepsis causes extensive morbidity and mortality in children worldwide. Prompt recognition and timely treatment of sepsis is critical in reducing morbidity and mortality. Genomic approaches are used to discover novel pathways, therapeutic targets and biomarkers. These may facilitate diagnosis and risk stratification to tailor treatment strategies.

Type: Article
Title: Transcriptional Instability during Evolving Sepsis May Limit Biomarker Based Risk Stratification.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0060501
Publisher version: http://dx.doi.org/10.1371/journal.pone.0060501
Language: English
Additional information: © 2013 Kwan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3609793
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1389421
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