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Primed Infusion with Delayed Equilibrium of Gd.DTPA for Enhanced Imaging of Small Pulmonary Metastases.

Kalber, TL; Campbell-Washburn, AE; Siow, BM; Sage, E; Price, AN; Ordidge, KL; Walker-Samuel, S; ... Lythgoe, MF; + view all (2013) Primed Infusion with Delayed Equilibrium of Gd.DTPA for Enhanced Imaging of Small Pulmonary Metastases. PLoS One , 8 (1) , Article e54903. 10.1371/journal.pone.0054903. Green open access

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Abstract

To use primed infusions of the magnetic resonance imaging (MRI) contrast agent Gd.DTPA (Magnevist), to achieve an equilibrium between blood and tissue (eqMRI). This may increase tumor Gd concentrations as a novel cancer imaging methodology for the enhancement of small tumor nodules within the low signal-to-noise background of the lung.

Type: Article
Title: Primed Infusion with Delayed Equilibrium of Gd.DTPA for Enhanced Imaging of Small Pulmonary Metastases.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0054903
Publisher version: http://dx.doi.org/10.1371/journal.pone.0054903
Language: English
Additional information: © 2013 Kalber et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The main funding for this study was provided by the Nanotech Grand Challenge Engineering and Physical Sciences Research Council (EPSRC) grant (EP/G06262072/1 - http://www.epsrc.ac.uk), the British Heart Foundation, the King’s College London and University College London Comprehensive Cancer Imaging Centre CR-UK & EPSRC, in association with the Medical Research Council (MRC) and Department of Health (England), and a Medical Research Council Capacity Building Studentship (KLO). This study was partly undertaken at UCLH/UCL who received a proportion of funding from the Department of Health’s NIHR Biomedical Research Centres funding scheme. SMJ is a Wellcome Trust Senior fellow in Clinical Science (WT091730MA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/1385438
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