Gehring, AJ;
Koh, S;
Chia, A;
Paramasivam, K;
Chew, VSP;
Ho, ZZ;
Lee, KH;
... Bertoletti, A; + view all
(2011)
Licensing Virus-Specific T Cells to Secrete the Neutrophil Attracting Chemokine CXCL-8 during Hepatitis B Virus Infection.
PLOS ONE
, 6
(8)
, Article e23330. 10.1371/journal.pone.0023330.
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Abstract
T cell functional plasticity helps tailor antiviral immunity during different phases of infections. We tested whether, during different phases of HBV infection, virus-specific T cells can acquire specific proinflammatory functions that could drive granulocyte/mononuclear cell liver infiltration. Multifunctional analysis of HBV-specific T cells during acute and chronic HBV infection revealed that HBV-specific T cells had the capacity to produce the neutrophil chemokine CXCL-8 but not IL-17. CXCL-8 producing T cells were detectable in the liver of chronic HBV patients with active hepatitis; while in acute HBV patients CXCL-8 production by T cells was temporally limited to the acute phase of disease, concomitant with the peak of liver inflammation. Characterization of the conditions necessary for the development of CXCL-8 producing T cells showed a requirement for IL-7 and IL-15 during T cell expansion. These data show that functional plasticity of virus-specific T cells spontaneously occurs during HBV infection and that an environment rich IL-7 and IL-15 can license T cells with the ability to produce CXCL-8 and potentially influence liver pathology.
| Type: | Article |
|---|---|
| Title: | Licensing Virus-Specific T Cells to Secrete the Neutrophil Attracting Chemokine CXCL-8 during Hepatitis B Virus Infection |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0023330 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0023330 |
| Language: | English |
| Additional information: | © 2011 Gehring et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Work was funded by the Agency for Science Technology and Research (A*STAR; http://www.a-star.edu.sg/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Keywords: | VIRAL CLEARANCE, HBV INFECTION, KILLER-CELLS, IN-VIVO, LYMPHOCYTES, IL-15, LIVER, DISEASE, RECRUITMENT, EXPRESSION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1381505 |
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