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Fatigue-associated alterations of cognitive function and electroencephalographic power densities.

Tanaka, M; Shigihara, Y; Funakura, M; Kanai, E; Watanabe, Y; (2012) Fatigue-associated alterations of cognitive function and electroencephalographic power densities. PLoS One , 7 (4) , Article e34774. 10.1371/journal.pone.0034774. Green open access

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Abstract

Fatigue is a common problem in modern society. We attempted to identify moderate- to long-term fatigue-related alterations in the central nervous system using cognitive tasks and electroencephalography (EEG) measures. The study group consisted of 17 healthy male participants. After saliva samples were collected to measure copy number of human herpesvirus (HHV)-6 DNA to assess the level of moderate- to long-term fatigue, subjects were evaluated using EEG, with their eyes open for 2 min, then closed for 1 min sitting quietly. Thereafter, they completed cognitive task trials to evaluate simple selective attention for 3 min (Task 1) and conflict-controlling selective attention for 6 min (Task 2, which included Stroop trials). The percent error of Task 2 for Stroop trials was positively associated with the copy number of saliva HHV-6 DNA, although the simple selective attention measures in Task 1 did not differ significantly. EEG power densities (especially the alpha power density) during the eye-closed condition were negatively associated with the saliva HHV-6 DNA level. Impaired high-level information processing such as that required for conflict-controlling selective attention in the central nervous system may be a characteristic feature of moderate- to long-term fatigue.

Type: Article
Title: Fatigue-associated alterations of cognitive function and electroencephalographic power densities.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0034774
Publisher version: http://dx.doi.org/10.1371/journal.pone.0034774
Language: English
Additional information: © 2012 Tanaka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported in part by the Grant-in-Aid for Scientific Research B (KAKENHI: 23300241) from Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received for this study. The authors have read the journal's policy and have the following conflicts: Etsuko Kanai and Masami Funakura are employees of Panasonic Corporation. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. Masaaki Tanaka, Yoshihito Shigihara, and Yasuyoshi Watanabe declare no conflict of interests.
Keywords: Adult, Cognition, DNA, Viral, Electroencephalography, Fatigue, Herpesvirus 6, Human, Humans, Male, Middle Aged, Young Adult
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1377904
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