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Multiple roles of the capsid protein in the early steps of HIV-1 infection.

Fassati, A; (2012) Multiple roles of the capsid protein in the early steps of HIV-1 infection. Virus Research , 170 (1-2) 15 - 24. 10.1016/j.virusres.2012.09.012. Green open access

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Abstract

The early steps of HIV-1 infection starting after virus entry into cells up to integration of its genome into host chromosomes are poorly understood. From seminal work showing that HIV-1 and oncoretroviruses follow different steps in the early stages post-entry, significant advances have been made in recent years and an important role for the HIV-1 capsid (CA) protein, the constituent of the viral core, has emerged. CA appears to orchestrate several events, such as virus uncoating, recognition by restriction factors and the innate immune system. It also plays a role in nuclear import and integration of HIV-1 and has become a novel target for antiretroviral drugs. Here we describe the different functions of CA and how they may be integrated into one or more coherent models that illuminate the early events in HIV-1 infection and their relations with the host cell.

Type: Article
Title: Multiple roles of the capsid protein in the early steps of HIV-1 infection.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.virusres.2012.09.012
Publisher version: http://dx.doi.org/10.1016/j.virusres.2012.09.012
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Active Transport, Cell Nucleus, Capsid Proteins, Cell Nucleus, HIV Infections, HIV-1, Humans, Reverse Transcription, Virus Integration, Virus Uncoating
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/1377801
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