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A window into the brain: an in vivo study of the retina in schizophrenia using optical coherence tomography.

Chu, EM; Kolappan, M; Barnes, TR; Joyce, EM; Ron, MA; (2012) A window into the brain: an in vivo study of the retina in schizophrenia using optical coherence tomography. Psychiatry Research: Neuroimaging , 203 (1) 89 - 94. 10.1016/j.pscychresns.2011.08.011. Green open access

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Abstract

Retinal nerve fibre layer (RNFL) thickness and macular volume (MV) can be measured in vivo using optical coherence tomography (OCT) providing a "window into the brain". RNFL and MV are promising biomarkers in neurological diseases. This study explores the potential of RNFL and MV to detect axonal abnormalities in vivo in schizophrenia and their correlations with clinical features. OCT was performed in 49 patients (38 schizophrenia, 11 schizoaffective disorder) and 40 healthy controls matched for age and gender. Group comparisons were made between whole retina and quadrant RNFL thickness and MV using multi-level analyses. In patients, associations were sought between RNFL and MV with symptom severity (positive/negative). Patients and controls had similar whole retina RNFL thickness (p=0.86) and MV (p=0.64), but RNFL in the right nasal quadrant of the schizoaffective group was thinner than in the schizophrenia group (p=0.02). In patients, positive symptom severity was associated with smaller MV (right β=-0.54, p=0.02; left β=-0.49, p=0.04). Normal MV and RNFL thickness suggests unmyelinated axons in patients with schizophrenia/schizoaffective disorder remain unaffected. Longitudinal studies using higher resolution OCT will clarify whether progressive RNFL and MV changes occur and whether they can be used as state or trait markers in schizophrenia.

Type: Article
Title: A window into the brain: an in vivo study of the retina in schizophrenia using optical coherence tomography.
Location: Ireland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pscychresns.2011.08.011
Publisher version: http://dx.doi.org/10.1016/j.pscychresns.2011.08.01...
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Adult, Case-Control Studies, Female, Humans, Linear Models, Macula Lutea, Male, Nerve Fibers, Organ Size, Psychotic Disorders, Retina, Schizophrenia, Severity of Illness Index, Tomography, Optical Coherence
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1377540
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