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The Depression in Visual Impairment Trial (DEPVIT): Trial design and protocol

Margrain, TH; Nollett, C; Shearn, J; Ryan, B; Smith, DJ; Stanford, M; Edwards, RT; ... Hegel, MT; + view all (2012) The Depression in Visual Impairment Trial (DEPVIT): Trial design and protocol. BMC Psychiatry , 12 , Article 57. 10.1186/1471-244X-12-57. Green open access

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Abstract

Background: The prevalence of depression in people with a visual disability is high but screening for depression and referral for treatment is not yet an integral part of visual rehabilitation service provision. One reason for this may be that there is no good evidence about the effectiveness of treatments in this patient group. This study is the first to evaluate the effect of depression treatments on people with a visual impairment and co morbid depression.Methods /design: The study is an exploratory, multicentre, individually randomised waiting list controlled trial. Participants will be randomised to receive Problem Solving Therapy (PST), a 'referral to the GP' requesting treatment according to the NICE's 'stepped care' recommendations or the waiting list arm of the trial. The primary outcome measure is change (from randomisation) in depressive symptoms as measured by the Beck's Depression Inventory (BDI-II) at 6 months. Secondary outcomes include change in depressive symptoms at 3 months, change in visual function as measured with the near vision subscale of the VFQ-48 and 7 item NEI-VFQ at 3 and 6 months, change in generic health related quality of life (EQ5D), the costs associated with PST, estimates of incremental cost effectiveness, and recruitment rate estimation.Discussion: Depression is prevalent in people with disabling visual impairment. This exploratory study will establish depression screening and referral for treatment in visual rehabilitation clinics in the UK. It will be the first to explore the efficacy of PST and the effectiveness of NICE's 'stepped care' approach to the treatment of depression in people with a visual impairment.Trial registration: ISRCTN46824140. © 2012 Margrain et al.; licensee BioMed Central Ltd.

Type: Article
Title: The Depression in Visual Impairment Trial (DEPVIT): Trial design and protocol
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-244X-12-57
Publisher version: http://dx.doi.org/10.1186/1471-244X-12-57
Language: English
Additional information: © 2012 Margrain et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1377168
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