Bardai, A;
Lamberts, RJ;
Blom, MT;
Spanjaart, AM;
Berdowski, J;
van der Staal, SR;
Brouwer, HJ;
... Tan, HL; + view all
(2012)
Epilepsy Is a Risk Factor for Sudden Cardiac Arrest in the General Population.
PLOS ONE
, 7
(8)
, Article e42749. 10.1371/journal.pone.0042749.
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Abstract
Background People with epilepsy are at increased risk for sudden death. The most prevalent cause of sudden death in the general population is sudden cardiac arrest (SCA) due to ventricular fibrillation (VF). SCA may contribute to the increased incidence of sudden death in people with epilepsy. We assessed whether the risk for SCA is increased in epilepsy by determining the risk for SCA among people with active epilepsy in a community-based study. Methods and Results This investigation was part of the Amsterdam Resuscitation Studies (ARREST) in the Netherlands. It was designed to assess SCA risk in the general population. All SCA cases in the study area were identified and matched to controls (by age, sex, and SCA date). A diagnosis of active epilepsy was ascertained in all cases and controls. Relative risk for SCA was estimated by calculating the adjusted odds ratios using conditional logistic regression (adjustment was made for known risk factors for SCA). We identified 1019 cases of SCA with ECG-documented VF, and matched them to 2834 controls. There were 12 people with active epilepsy among cases and 12 among controls. Epilepsy was associated with a three-fold increased risk for SCA (adjusted OR 2.9 [95%CI 1.1–8.0.], p = 0.034). The risk for SCA in epilepsy was particularly increased in young and females. Conclusion Epilepsy in the general population seems to be associated with an increased risk for SCA.
| Type: | Article |
|---|---|
| Title: | Epilepsy Is a Risk Factor for Sudden Cardiac Arrest in the General Population |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0042749 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0042749 |
| Language: | English |
| Additional information: | © Bardai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. HLT was supported by the Netherlands Organization for Scientific Research (NWO, grant ZonMW Vici 918.86.616), the Dutch Medicines Evaluation Board (MEB/CBG), and the National Epilepsy Foundation Netherlands. The Arrest data collection was supported by an unconditional grant from Physio Control and a grant from the Netherlands Heart Foundation (grant 2006B179). AB was supported by the Netherlands Organization for Scientific Research (NWO, grant Mozaiek 017.003.084). RDT and JWS are part of the Prevention and Risk Identification of SUDEP Mortatlity Consortium which is funded by the National Institutes of Health (National Board of Industrial Health/National Institute of Neurological Disorders and Stroke -1P20NS076965-01). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Correction:There were errors in the Funding section. The correct funding information is as follows: HLT was supported by the Netherlands Organization for Scientific Research (NWO, grant ZonMW Vici 918.86.616), and the Dutch Medicines Evaluation Board (MEB/CBG). HLT, RDT, and JWS are supported by the National Epilepsy Foundation Netherlands (project number 10-07). The Arrest data collection was supported by an unconditional grant from Physio Control and a grant from the Netherlands Heart Foundation (grant 2006B179). Dr. Bardai was supported by the Netherlands Organization for Scientific Research (NWO, grant Mozaiek 017.003.084). RD Thijs and JW Sander are part of PRISM - the Prevention and Risk Identification of SUDEP Mortality Consortium which is funded by the NIH (NBIH/NINDS -1P20NS076965-01). The funders were not involved in: design, conduct of the study, collection, management, analysis, interpretation of the data, preparation, review or approval of the manuscript. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1376855 |
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