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Severe respiratory syncytial virus bronchiolitis in infants is associated with reduced airway interferon gamma and substance P.

Semple, MG; Dankert, HM; Ebrahimi, B; Correia, JB; Booth, JA; Stewart, JP; Smyth, RL; (2007) Severe respiratory syncytial virus bronchiolitis in infants is associated with reduced airway interferon gamma and substance P. PLOS One , 2 (10) , Article e1038. 10.1371/journal.pone.0001038. Green open access

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Abstract

Severe human respiratory syncytial virus (hRSV) bronchiolitis in previously well infants may be due to differences in the innate immune response to hRSV infection. Aim: to determine if factors mediating proposed mechanisms for severe bronchiolitis differ with severity of disease.

Type: Article
Title: Severe respiratory syncytial virus bronchiolitis in infants is associated with reduced airway interferon gamma and substance P.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0001038
Publisher version: http://dx.doi.org/10.1371/journal.pone.0001038
Language: English
Additional information: © 2007 Semple et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This study was funded by a National Clinician Scientist Award to Dr MG Semple by the Department of Health, HMG United Kingdom. This study was supported by an equipment grant from the Royal Liverpool Children's Hospital (Alder Hey) Endowment Fund. Oral presentation of this data at The 2006 American Thoracic Society International Conference San Diego USA was supported by an International Trainee Travel Award to MGS from the American Thoracic Society. None of the sponsors had any role in the study design, execution or writing of this paper.
Keywords: Bronchiolitis, Female, Humans, Immunity, Innate, Infant, Infant, Newborn, Interferon-gamma, Interleukin-9, Male, Oxygen, Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus, Human, Respiratory System, Substance P, Urea
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1375491
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