Groen, D;
Borgdorff, J;
Bona-Casas, C;
Hetherington, J;
Nash, RW;
Zasada, SJ;
Saverchenko, I;
... Coveney, PV; + view all
(2013)
Flexible composition and execution of high performance, high fidelity multiscale biomedical simulations.
Interface Focus
, 3
(2)
, Article 20120087. 10.1098/rsfs.2012.0087.
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Abstract
Multiscale simulations are essential in the biomedical domain to accurately model human physiology. We present a modular approach for designing, constructing and executing multiscale simulations on a wide range of resources, from laptops to petascale supercomputers, including combinations of these. Our work features two multiscale applications, in-stent restenosis and cerebrovascular bloodflow, which combine multiple existing single-scale applications to create a multiscale simulation. These applications can be efficiently coupled, deployed and executed on computers up to the largest (peta) scale, incurring a coupling overhead of 1–10% of the total execution time.
| Type: | Article |
|---|---|
| Title: | Flexible composition and execution of high performance, high fidelity multiscale biomedical simulations |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1098/rsfs.2012.0087 |
| Publisher version: | http://dx.doi.org/10.1098/rsfs.2012.0087 |
| Language: | English |
| Additional information: | © 2013 The Author(s) Published by the Royal Society. All rights reserved. This is the authors' accepted version of this published article. |
| Keywords: | multiscale modelling, blood flow, high performance computing, in-stent restenosis, cerebrovascular bloodflow, distributed computing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1373098 |
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