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Flexible composition and execution of high performance, high fidelity multiscale biomedical simulations

Groen, D; Borgdorff, J; Bona-Casas, C; Hetherington, J; Nash, RW; Zasada, SJ; Saverchenko, I; ... Coveney, PV; + view all (2013) Flexible composition and execution of high performance, high fidelity multiscale biomedical simulations. Interface Focus , 3 (2) , Article 20120087. 10.1098/rsfs.2012.0087. Green open access

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Abstract

Multiscale simulations are essential in the biomedical domain to accurately model human physiology. We present a modular approach for designing, constructing and executing multiscale simulations on a wide range of resources, from laptops to petascale supercomputers, including combinations of these. Our work features two multiscale applications, in-stent restenosis and cerebrovascular bloodflow, which combine multiple existing single-scale applications to create a multiscale simulation. These applications can be efficiently coupled, deployed and executed on computers up to the largest (peta) scale, incurring a coupling overhead of 1–10% of the total execution time.

Type: Article
Title: Flexible composition and execution of high performance, high fidelity multiscale biomedical simulations
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rsfs.2012.0087
Publisher version: http://dx.doi.org/10.1098/rsfs.2012.0087
Language: English
Additional information: © 2013 The Author(s) Published by the Royal Society. All rights reserved. This is the authors' accepted version of this published article.
Keywords: multiscale modelling, blood flow, high performance computing, in-stent restenosis, cerebrovascular bloodflow, distributed computing
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1373098
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