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The enigmatic root cell - Emerging roles contributing to fluid homeostasis within the cochlear outer sulcus.

Jagger, DJ; Forge, A; (2013) The enigmatic root cell - Emerging roles contributing to fluid homeostasis within the cochlear outer sulcus. Hearing Research , 303 pp. 1-11. 10.1016/j.heares.2012.10.010. Green open access

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Abstract

Despite their curious morphology prompting numerous hypotheses of their normal function, the root cells lining the cochlear outer sulcus have long evaded physiological characterization. A growing body of evidence now suggests that they regulate the solute content of the endolymph and/or the perilymph, and may be essential in safe-guarding the global homeostasis of the cochlea. Immuno-labeling experiments have demonstrated polarized expression of key ion transport proteins, and recent electrophysiological recordings have identified specific membrane conductances. These studies have painted a clearer picture of how this unusual cell type may contribute to the maintenance of sound transduction, and how they may be central to pathological processes associated with various forms of hearing loss.

Type: Article
Title: The enigmatic root cell - Emerging roles contributing to fluid homeostasis within the cochlear outer sulcus.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.heares.2012.10.010
Publisher version: http://dx.doi.org/10.1016/j.heares.2012.10.010
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/1373021
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