Pai, Y-J;
Abdullah, NL;
Mohd-Zin, SW;
Mohammed, RS;
Rolo, A;
Greene, NDE;
Abdul-Aziz, NM;
(2012)
Epithelial fusion during neural tube morphogenesis.
Birth Defects Research Part A: Clinical and Molecular Teratology
, 94
(10)
pp. 817-823.
10.1002/bdra.23072.
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Abstract
Adhesion and fusion of epithelial sheets marks the completion of many morphogenetic events during embryogenesis. Neural tube closure involves an epithelial fusion sequence in which the apposing neural folds adhere initially via cellular protrusions, proceed to a more stable union, and subsequently undergo remodeling of the epithelial structures to yield a separate neural tube roof plate and overlying nonneural ectoderm. Cellular protrusions comprise lamellipodia and filopodia, and studies in several different systems emphasize the critical role of RhoGTPases in their regulation. How epithelia establish initial adhesion is poorly understood but, in neurulation, may involve interactions between EphA receptors and their ephrinA ligands. Epithelial remodeling is spatially and temporally correlated with apoptosis in the dorsal neural tube midline, but experimental inhibition of this cell death does not prevent fusion and remodeling. A variety of molecular signaling systems have been implicated in the late events of morphogenesis, but genetic redundancy, for example among the integrins and laminins, makes identification of the critical players challenging. An improved understanding of epithelial fusion can provide insights into normal developmental processes and may also indicate the mode of origin of clinically important birth defects.
| Type: | Article |
|---|---|
| Title: | Epithelial fusion during neural tube morphogenesis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/bdra.23072 |
| Publisher version: | http://dx.doi.org/10.1002/bdra.23072 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Toxicology, DEVELOPMENTAL BIOLOGY, TOXICOLOGY, epithelium, adhesion, fusion, lamellipodia, filopodia, apoptosis, neurulation, neural tube defects, spina bifida, morphogenesis, DROSOPHILA DORSAL CLOSURE, PROGRAMMED CELL-DEATH, MOUSE EMBRYOS, MAMMALIAN DEVELOPMENT, ACTIN POLYMERIZATION, SPINA-BIFIDA, MICE LACKING, N-CADHERIN, APOPTOSIS, NEURULATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1368778 |
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