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CRYSTAL AND MOLECULAR-STRUCTURE OF 8,2'-CYCLOADENOSINE TRIHYDRATE

NEIDLE, S; TAYLOR, G; COWLING, P; (1979) CRYSTAL AND MOLECULAR-STRUCTURE OF 8,2'-CYCLOADENOSINE TRIHYDRATE. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE , 35 (Part 3) 708 - 712. 10.1107/S0567740879004490. Green open access

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Abstract

8,2'-Cycloadenosine, C IoHi~NsO4.3H20, is a modified arabinosyladenosine nucleoside which has been cyclized at the C(8) and 0(2') atoms. THe trihydrate crystallizes in the orthorhombic space group P2~2~2~, with a = 8.680 (2), b = 5.991 (2), c = 27.203 (4) A, Z = 4. The structure was refined to R = 0.0672 for 1411 unique reflections, photographically recorded. The arabinofuranose ring has a flattened C(4')-endo-C(3')- exo pucker. The conformation about C(4')-C(5') is gauche-gauche, and that about the sugar-base bond is high anti. The crystal structure involves extensive base-base hydrogen bonding, N(1), N(6) and N(7) all being participants.

Type: Article
Title: CRYSTAL AND MOLECULAR-STRUCTURE OF 8,2'-CYCLOADENOSINE TRIHYDRATE
Open access status: An open access version is available from UCL Discovery
DOI: 10.1107/S0567740879004490
Publisher version: http://scripts.iucr.org/cgi-bin/paper?S05677408790...
Language: English
Additional information: Copyright © International Union of Crystallography
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: https://discovery.ucl.ac.uk/id/eprint/1367864
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