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Licensing of γδT cells for professional antigen presentation: A new role for antibodies in regulation of antitumor immune responses

Anderson, J; Gustafsson, K; Himoudi, N; Yan, M; Heuijerjans, J; (2012) Licensing of γδT cells for professional antigen presentation: A new role for antibodies in regulation of antitumor immune responses. Oncoimmunology , 1 (9) 1652 -1654. 10.4161/onci.21971. Green open access

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Abstract

Following activation, γδ T cells display many properties of lymphocytes from the innate immune system, yet how they mediate antigen presentation remains an open conundrum. In humans, circulating γδ T cells that express the Vγ9Vδ2 T-cell receptor become reversibly licensed for professional antigen presentation only upon interaction with a target cell opsonized with IgGs.

Type: Article
Title: Licensing of γδT cells for professional antigen presentation: A new role for antibodies in regulation of antitumor immune responses
Open access status: An open access version is available from UCL Discovery
DOI: 10.4161/onci.21971
Publisher version: http://dx.doi.org/10.4161/onci.21971
Language: English
Additional information: This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. PMCID: PMC3525635
Keywords: γδT cells, Antibody opsonisation, Antigen presentation, APC, CD16, Licensing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1366190
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