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Perirhinal contributions to human visual perception

Devlin, JT; Price, CJ; (2007) Perirhinal contributions to human visual perception. Current Biology , 17 (17) 1484 - 1488. 10.1016/j.cub.2007.07.066. Green open access

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Abstract

Medial temporal lobe (MTL) structures including the hippocampus, entorhinal cortex, and perirhinal cortex are thought to be part of a unitary system dedicated to memory [1, 2], although recent studies suggest that at least one component-perirhinal cortex-might also contribute to perceptual processing [3-6]. To date, the strongest evidence for this comes from animal lesion studies [7-14]. In contrast, the findings from human patients with naturally occurring MTL lesions are less clear and suggest a possible functional difference between species [15-20]. Here, both these issues were addressed with functional neuroimaging in healthy volunteers performing a perceptual discrimination task originally developed for monkeys [7]. This revealed perirhinal activation when the task required the integration of visual features into a view-invariant representation but not when it could be accomplished on the basis of simple features (e.g., color and shape). This activation pattern matched lateral inferotemporal regions classically associated with visual processing but differed from entorhinal cortex associated with memory encoding. The results demonstrate a specific role for the perirhinal cortex in visual perception and establish a functional homology for perirhinal cortex between species, although we propose that in humans, the region contributes to a wider behavioral repertoire including mnemonic, perceptual, and linguistic processes.

Type: Article
Title: Perirhinal contributions to human visual perception
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cub.2007.07.066
Publisher version: http://dx.doi.org/10.1016/j.cub.2007.07.066
Language: English
Additional information: An Open Access Elsevier publication.
Keywords: Medial temporal-lobe, object recognition, cortex ablation, double dissociation, prefrontal cortex, field potentials, working-memory, rhinal cortex, discrimination, monkeys
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/136413
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