UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Tracking changes following spinal cord injury: insights from neuroimaging.

Freund, P; Curt, A; Friston, K; Thompson, A; (2013) Tracking changes following spinal cord injury: insights from neuroimaging. Neuroscientist , 19 (2) 116 - 128. 10.1177/1073858412449192. Green open access

[thumbnail of Neuroscientist-2013-Freund-116-28.pdf]
Preview
PDF
Neuroscientist-2013-Freund-116-28.pdf

Download (4MB)

Abstract

Traumatic spinal cord injury is often disabling and recovery of function is limited. As a consequence of damage, both spinal cord and brain undergo anatomical and functional changes. Besides clinical measures of recovery, biomarkers that can detect early anatomical and functional changes might be useful in determining clinical outcome-during the course of rehabilitation and recovery-as well as furnishing a tool to evaluate novel treatment interventions and their mechanisms of action. Recent evidence suggests an interesting three-way relationship between neurological deficit and changes in the spinal cord and of the brain and that, importantly, noninvasive magnetic resonance imaging techniques, both structural and functional, provide a sensitive tool to lay out these interactions. This review describes recent findings from multimodal imaging studies of remote anatomical changes (i.e., beyond the lesion site), cortical reorganization, and their relationship to clinical disability. These developments in this field may improve our understanding of effects on the nervous system that are attributable to the injury itself and will allow their distinction from changes that result from rehabilitation (i.e., functional retraining) and from interventions affecting the nervous system directly (i.e., neuroprotection or regeneration).

Type: Article
Title: Tracking changes following spinal cord injury: insights from neuroimaging.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1073858412449192
Publisher version: http://dx.doi.org/10.1177/1073858412449192
Language: English
Additional information: © The Author(s) 2012. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm). PMCID: PMC4107798
Keywords: Humans, Neuroimaging, Neuronal Plasticity, Recovery of Function, Spinal Cord, Spinal Cord Injuries
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1361948
Downloads since deposit
105Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item