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Differential impact of risk factors for women and men on the risk of major depressive disorder.

Stegenga, BT; King, M; Grobbee, DE; Torres-González, F; Švab, I; Maaroos, HI; Xavier, M; ... Geerlings, MI; + view all (2012) Differential impact of risk factors for women and men on the risk of major depressive disorder. Annals of Epidemiology , 22 (6) 388 - 396. 10.1016/j.annepidem.2012.04.011. Green open access

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Abstract

Purpose: Our aim is to examine which risk factors have a greater impact in women than in men on the risk of major depressive disorder (MDD) and whether factors differ between a possible recurrent MDD and a first onset of MDD. Methods: Prospective cohort study of general practice attendees in seven countries, who were followed up at 6 and 12 months (predictD). Absolute risk differences (interaction contrast) across sex for onset of DSM-IV MDD after 6 or 12 months of follow-up were estimated for 35 risk factors from 7101 participants without MDD at baseline. Results: A total of 599 participants (80% female) had an onset of MDD at 6 or 12 months. Most risk factors had a greater impact in women than in men on the risk of MDD and were not restricted to a specific class of risk factors. After we stratified for a history of depressive symptoms, we found that the impact of risk factors across sex was generally stronger on possible recurrent MDD than on a first onset of MDD. Conclusions: Our findings may partly account for the observed difference in incidence of MDD between men and women.

Type: Article
Title: Differential impact of risk factors for women and men on the risk of major depressive disorder.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.annepidem.2012.04.011
Publisher version: http://dx.doi.org/10.1016/j.annepidem.2012.04.011
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3657146
Keywords: Adolescent, Adult, Aged, Depressive Disorder, Major, Female, General Practice, Humans, Incidence, Male, Middle Aged, Prospective Studies, Risk Factors, Sex Factors, Young Adult
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1354928
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