Jury, EC;
Flores-Borja, F;
Kabouridis, PS;
(2007)
Lipid rafts in T cell signalling and disease.
[Review].
Seminars in Cell & Developmental Biology
, 18
(5)
608 - 615.
10.1016/j.semcdb.2007.08.002.
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Abstract
Lipid rafts is a blanket term used to describe distinct areas in the plasma membrane rich in certain lipids and proteins and which are thought to perform diverse functions. A large number of studies report on lipid rafts having a key role in receptor signalling and activation of lymphocytes. In T cells, lipid raft involvement was demonstrated in the early steps during T cell receptor (TCR) stimulation. Interestingly, recent evidence has shown that signalling in these domains differs in T cells isolated from patients with autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Here, we discuss these findings and explore the potential of lipid rafts as targets for the development of a new class of agents to downmodulate immune responses and for the treatment of autoimmune diseases.
| Type: | Article |
|---|---|
| Title: | Lipid rafts in T cell signalling and disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.semcdb.2007.08.002 |
| Publisher version: | http://dx.doi.org/10.1016/j.semcdb.2007.08.002 |
| Language: | English |
| Additional information: | An Open Access Elsevier publication. |
| Keywords: | Lipid rafts, T cell, lupus, autoimmunity, review, systemic-lupus-erythematosus, protein-tyrosine kinase, receptor zeta-chain, redox balance alterations, antigen receptor, plasma-membrane, immunological synapse, rheumatoid-arthritis, peripheral-blood, adapter protein |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/135188 |
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