UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

A few aspects of transonychial water loss (TOWL): inter-individual, and intra-individual inter-finger, inter-hand and inter-day variabilities, and the influence of nail plate hydration, filing and varnish

Murdan, S; Hinsu, D; Guimier, M; (2008) A few aspects of transonychial water loss (TOWL): inter-individual, and intra-individual inter-finger, inter-hand and inter-day variabilities, and the influence of nail plate hydration, filing and varnish. European Journal of Pharmaceutics and Biopharmaceutics , 70 (2) 684 - 689. 10.1016/j.ejpb.2008.05.018. Green open access

[thumbnail of Murdan_TOWL_for_website.pdf]
Preview
PDF
Murdan_TOWL_for_website.pdf

Download (363kB)

Abstract

The aim of the study was to measure transonychial water loss (TOWL) in order to identify the extent of inter-individual, intra-individual inter-finger, inter-hand, and inter-day variabilities, and the influence of nail wetting, filing and varnishing on TOWL, with a view to determine parameters for the measurement of TOWL and its possible applications. Fingernail and toenail TOWL was measured using the condenser-chamber AquaFlux (Biox) and a specially designed Nail Adaptor supplied by Biox. A wide range of TOWL values (28–75 g/m2 h for fingernails and 26–48 g/m2 h for toenails) were found, with significant inter-individual variability. Intra-individual variability was lower; however, in the same individual, inter-finger, inter-hand/foot and inter-day variabilities were found, as well as a strong correlation between nail plate thickness and TOWL. Wetting the nails, even briefly, resulted in a significant rise in TOWL, which subsequently took much longer to return to control values. Filing the nail plate surface with a pharmaceutical file caused large increases in TOWL, whose profile (with number of filing strokes) was fairly different among individuals. As expected, nail varnish application reduced TOWL; the different extent of TOWL reduction by different varnishes suggests a potential use of TOWL measurements for product comparisons.

Type: Article
Title: A few aspects of transonychial water loss (TOWL): inter-individual, and intra-individual inter-finger, inter-hand and inter-day variabilities, and the influence of nail plate hydration, filing and varnish
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ejpb.2008.05.018
Publisher version: http://dx.doi.org/10.1016/j.ejpb.2008.05.018
Language: English
Additional information: NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in the European Journal of Pharmaceutics and Biopharmaceutics, 70:2 (2008), http://dx.doi.org/10.1016/j.ejpb.2008.05.018
Keywords: Nail, ungual, transonychial water loss, TOWL, topical therapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/1351479
Downloads since deposit
644Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item