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Mechanical stimulation of 3D bio-engineered skeletal muscle

Player, DJ; Martin, NRW; Castle, PC; Passey, S; Sharples, AP; Mudera, V; Lewis, MP; (2011) Mechanical stimulation of 3D bio-engineered skeletal muscle. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 19-21 July 2011, University of Leeds. (pp. 38 - 38). Green open access

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Abstract

Skeletal muscle is a highly plastic tissue, responding to exercise and mechanical loading. In vitro culture systems have been used to replicate this mechanical stimulus in order to study cellular and molecular adaptations. Previous research using such models has often lacked bio-mimicity, with respect to the in vitro culture, the mechanical loading, or both. This has lead to contradictory findings with regards to a variety of molecular outputs. Cell culture matrix and environment (2D or 3D), the type of mechanical loading (uni-axial or multi-axial) and the extent, speed and duration of stretching, are all likely to affect the adaptive responses of the cells and their maturation into functional muscle models. It is therefore necessary to develop a model which has greater physiological relevance if such models are to be used to further understand in vivo physiology.

Type: Proceedings paper
Title: Mechanical stimulation of 3D bio-engineered skeletal muscle
Event: Tissue and Cell Engineering Society (TCES) meeting
Location: University of Leeds
Dates: 19/07/2011-21/07/2011
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.ecmjournal.org/journal/supplements/vol0...
Language: English
Additional information: Reproduced with kind permission from eCM journal (www.ecmjournal.org)
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/1348473
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